ENhANCE trial protocol: A multi-centre, randomised, phase IV trial comparing the efficacy of oxycodone/naloxone prolonged release (OXN PR) versus oxycodone prolonged release (Oxy PR) tablets in patients with advanced cancer.

Wong, Aaron K; Grobler, Anneke; Le, Brian

Wong, Aaron K; Grobler, Anneke; Le, Brian.

Afiliação

Wong AK; Department of Palliative Care Peter MacCallum Cancer Centre, 305 Grattan St, Melbourne, Victoria, 3000, Australia.
Grobler A; The Royal Melbourne Hospital, 300 Grattan St, Parkville, Victoria, 3050, Australia.
Le B; Department of Medicine, University of Melbourne, Eastern Hill Campus, Victoria Parade, Fitzroy, Victoria, 3065, Australia.

Contemp Clin Trials Commun ; 30: 101036, 2022 Dec.

Article em En | MEDLINE | ID: mdl-36407843

Palavras-chave

Analgesics; BFI, Bowel Function Index; BPI SF, Brief Pain Inventory Short Form; CKD-EPI, Chronic Kidney Disease Epidemiology Collaboration calculation; Constipation; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire; GEE, Generalised Estimating Equations; ITT, Intention To Treat; Neoplasms; OIC, opioid-induced constipation; OXN PR, oxycodone/naloxone prolonged release; Opioid; Oxy PR, oxycodone prolonged release; PRO CoMiDa, Patient Reported Outcome Completion and Missing Data Checklist; PRO, Patient Reported Outcome; Pain; Palliative care; S-LANSS, Leeds Assessment of Neuropathic Symptoms & Signs

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Clinical_trials / Prognostic_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article