The alkaloids with neuroprotective effect from the root bark of Ailanthus altissima.
Nat Prod Res
; 37(22): 3751-3757, 2023.
Article
em En
| MEDLINE
| ID: mdl-36416576
ABSTRACT
The chemical constituent investigation on the root bark of Ailanthus altissima leads to the isolation of a new ß-carboline alkaloid, 14(S),15-dihydroxy-6-methoxy-ß-carboline (1), along with nine known alkaloids. The structure of new compound was elucidated on basis of extensive spectroscopic analysis, especially two-dimensional (2D) NMR techniques and the absolute configuration of C-14 was determined by ECD calculation. The neuroprotective effect of the isolated compounds on PC12 cells against the serum deprivation injury was evaluated by MTT method. As a result, compound 7 revealed protective effect on PC12 cells and the cell survival rate was significantly increased.
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MEDLINE
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En
Ano de publicação:
2023
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Article