Deoxyelephantopin, a germacrane-type sesquiterpene lactone from Elephantopus scaber, induces mitochondrial apoptosis of hepatocarcinoma cells by targeting Hsp90&#945; in vitro and in vivo.

Chen, Jing-Jie; Yan, Qiu-Lin; Bai, Ming; Liu, Qingbo; Song, Shao-Jiang; Yao, Guo-Dong

Deoxyelephantopin, a germacrane-type sesquiterpene lactone from Elephantopus scaber, induces mitochondrial apoptosis of hepatocarcinoma cells by targeting Hsp90α in vitro and in vivo.

Chen, Jing-Jie; Yan, Qiu-Lin; Bai, Ming; Liu, Qingbo; Song, Shao-Jiang; Yao, Guo-Dong.

Afiliação

Chen JJ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Yan QL; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Bai M; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Liu Q; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Song SJ; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.
Yao GD; Key Laboratory of Computational Chemistry-Based Natural Antitumor Drug Research & Development, School of Traditional Chinese Materia Medica, Shenyang Pharmaceutical University, Shenyang, China.

Phytother Res ; 37(2): 702-716, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36420857

Assuntos

Asteraceae; Carcinoma Hepatocelular; Neoplasias Hepáticas; Sesquiterpenos; Humanos; Sesquiterpenos de Germacrano/farmacologia; Carcinoma Hepatocelular/tratamento farmacológico; Sorafenibe/farmacologia; Simulação de Acoplamento Molecular; Neoplasias Hepáticas/tratamento farmacológico; Apoptose; Lactonas/farmacologia; Lactonas/química; Sesquiterpenos/farmacologia; Sesquiterpenos/química; Mitocôndrias; Asteraceae/química; Linhagem Celular Tumoral

Palavras-chave

Elephantopus scaber Linn.; Hsp90α; apoptosis; deoxyelephantopin; oxidative stress

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Carcinoma Hepatocelular / Asteraceae / Neoplasias Hepáticas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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