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Functional Nutrients to Ameliorate Neurogenic Muscle Atrophy.
Moresi, Viviana; Renzini, Alessandra; Cavioli, Giorgia; Seelaender, Marilia; Coletti, Dario; Gigli, Giuseppe; Cedola, Alessia.
Afiliação
  • Moresi V; Institute of Nanotechnology, c/o Sapienza University of Rome, National Research Council (CNR-NANOTEC), 00185 Rome, Italy.
  • Renzini A; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, Italy.
  • Cavioli G; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, Italy.
  • Seelaender M; Department of Surgery, Cancer Metabolism Research Group, LIM 26-HC, Faculty of Medicine, University of São Paulo, São Paulo 01246-903, Brazil.
  • Coletti D; Unit of Histology and Medical Embryology, Department of Anatomy, Histology, Forensic Medicine and Orthopaedics, Sapienza University of Rome, 00185 Rome, Italy.
  • Gigli G; Sorbonne Université, CNRS, INSERM, Institut de Biologie Paris-Seine (IBPS), Biological Adaptation and Aging (B2A), F-75005 Paris, France.
  • Cedola A; Institute of Nanotechnology, c/o Campus Ecotekne, National Research Council (CNR-NANOTEC), 73100 Lecce, Italy.
Metabolites ; 12(11)2022 Nov 21.
Article em En | MEDLINE | ID: mdl-36422289
Neurogenic muscle atrophy is a debilitating condition that occurs from nerve trauma in association with diseases or during aging, leading to reduced interaction between motoneurons and skeletal fibers. Current therapeutic approaches aiming at preserving muscle mass in a scenario of decreased nervous input include physical activity and employment of drugs that slow down the progression of the condition yet provide no concrete resolution. Nutritional support appears as a precious tool, adding to the success of personalized medicine, and could thus play a relevant part in mitigating neurogenic muscle atrophy. We herein summarize the molecular pathways triggered by denervation of the skeletal muscle that could be affected by functional nutrients. In this narrative review, we examine and discuss studies pertaining to the use of functional ingredients to counteract neurogenic muscle atrophy, focusing on their preventive or curative means of action within the skeletal muscle. We reviewed experimental models of denervation in rodents and in amyotrophic lateral sclerosis, as well as that caused by aging, considering the knowledge generated with use of animal experimental models and, also, from human studies.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article