Guggulsterone inhibits migration and invasion through proteasomal and lysosomal degradation in human glioblastoma cells.

Yang, Jen-Fu; Chen, Tzu-Min; Chang, Hsin-Han; Tsai, Yu-Ling; Tsai, Wen-Chiuan; Huang, Wen-Yen; Lo, Cheng-Hsiang; Lin, Chun-Shu; Shen, Po-Chien; Chen, Ying

Yang, Jen-Fu; Chen, Tzu-Min; Chang, Hsin-Han; Tsai, Yu-Ling; Tsai, Wen-Chiuan; Huang, Wen-Yen; Lo, Cheng-Hsiang; Lin, Chun-Shu; Shen, Po-Chien; Chen, Ying.

Afiliação

Yang JF; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chen TM; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Chang HH; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan.
Tsai YL; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Tsai WC; Department of Pathology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Huang WY; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Institute of Clinical Medicine, National Yang-Ming University, Taipei, Taiwan.
Lo CH; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Lin CS; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan; Graduate Institute of Clinical Medicine, Taipei Medical University, Taipei, Taiwan.
Shen PC; Department of Radiation Oncology, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Chen Y; Department of Biology and Anatomy, National Defense Medical Center, Taipei, Taiwan. Electronic address: ychen0523@mail.ndmctsgh.edu.tw.

Eur J Pharmacol ; 938: 175411, 2023 Jan 05.

Article em En | MEDLINE | ID: mdl-36436590

Assuntos

Neoplasias Encefálicas; Glioblastoma; Humanos; Animais; Camundongos; Glioblastoma/patologia; Metaloproteinase 2 da Matriz/metabolismo; Catepsina B; Linhagem Celular Tumoral; Neoplasias Encefálicas/patologia; Movimento Celular; Complexo de Endopeptidases do Proteassoma/metabolismo; Lisossomos/metabolismo; Invasividade Neoplásica

Palavras-chave

Autophagy; Glioblastoma; Guggulsterone; Invasion; Migration; Protein degradation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioblastoma Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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