Trends in oral small-molecule drug discovery and product development based on product launches before and after the Rule of Five.

Stegemann, Sven; Moreton, Chris; Svanbäck, Sami; Box, Karl; Motte, Geneviève; Paudel, Amrit

Stegemann, Sven; Moreton, Chris; Svanbäck, Sami; Box, Karl; Motte, Geneviève; Paudel, Amrit.

Afiliação

Stegemann S; Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13, 8010 Graz, Austria. Electronic address: sven.stegemann@tugraz.at.
Moreton C; FinnBrit Consulting, Waltham, MA, USA.
Svanbäck S; The Solubility Company Ltd, Viikinkaari 4, 00790 Helsinki, Finland.
Box K; Pion Inc. (UK) Ltd, Forest Row, UK.
Motte G; JEN Pharma Consulting, 182 Rue Henri Latour, 1450 Chastre, Belgium.
Paudel A; Institute for Process and Particle Engineering, Graz University of Technology, Inffeldgasse 13, 8010 Graz, Austria; Research Center Pharmaceutical Engineering GmbH, Inffeldgasse 13, 8010 Graz, Austria.

Drug Discov Today ; 28(2): 103344, 2023 02.

Article em En | MEDLINE | ID: mdl-36442594

Assuntos

Desenho de Fármacos; Descoberta de Drogas; Preparações Farmacêuticas/química; Química Farmacêutica; Bibliotecas de Moléculas Pequenas

Palavras-chave

Rule of Five; chemical trends; druggability; medicinal chemistry; oral drug delivery; poor solubility

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Desenho de Fármacos / Descoberta de Drogas Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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