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A meta-analysis of pre-pregnancy maternal body mass index and placental DNA methylation identifies 27 CpG sites with implications for mother-child health.
Fernandez-Jimenez, Nora; Fore, Ruby; Cilleros-Portet, Ariadna; Lepeule, Johanna; Perron, Patrice; Kvist, Tuomas; Tian, Fu-Ying; Lesseur, Corina; Binder, Alexandra M; Lozano, Manuel; Martorell-Marugán, Jordi; Loke, Yuk J; Bakulski, Kelly M; Zhu, Yihui; Forhan, Anne; Sammallahti, Sara; Everson, Todd M; Chen, Jia; Michels, Karin B; Belmonte, Thalia; Carmona-Sáez, Pedro; Halliday, Jane; Daniele Fallin, M; LaSalle, Janine M; Tost, Jorg; Czamara, Darina; Fernández, Mariana F; Gómez-Martín, Antonio; Craig, Jeffrey M; Gonzalez-Alzaga, Beatriz; Schmidt, Rebecca J; Dou, John F; Muggli, Evelyne; Lacasaña, Marina; Vrijheid, Martine; Marsit, Carmen J; Karagas, Margaret R; Räikkönen, Katri; Bouchard, Luigi; Heude, Barbara; Santa-Marina, Loreto; Bustamante, Mariona; Hivert, Marie-France; Bilbao, Jose Ramon.
Afiliação
  • Fernandez-Jimenez N; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute, Leioa, Basque Country, Spain.
  • Fore R; Department of Population Medicine, Harvard Medical School and Harvard Pilgrim Health Care Institute, Boston, MA, USA.
  • Cilleros-Portet A; Department of Genetics, Physical Anthropology and Animal Physiology, University of the Basque Country (UPV/EHU) and Biocruces-Bizkaia Health Research Institute, Leioa, Basque Country, Spain.
  • Lepeule J; University Grenoble Alpes, Inserm, CNRS, Team of Environmental Epidemiology Applied to Reproduction and Respiratory Health, IAB, Grenoble, France.
  • Perron P; Centre de Recherche du Centre Hospitalier Universitaire de Sherbrooke (CHUS), Sherbrooke, QC, Canada.
  • Kvist T; Department of Psychology and Logopedics, University of Helsinki, Helsinki, Finland.
  • Tian FY; Gangarosa Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.
  • Lesseur C; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • Binder AM; Cancer Epidemiology Program, University of Hawaii Cancer Center, Honolulu, HI, USA.
  • Lozano M; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
  • Martorell-Marugán J; Epidemiology and Environmental Health Joint Research Unit, FISABIO-Universitat Jaume I-Universitat de València, Valencia, Spain.
  • Loke YJ; Preventive Medicine and Public Health, Food Sciences, Toxicology and Forensic Medicine Department, Universitat de València, Valencia, Spain.
  • Bakulski KM; Department of Statistics and Operations Research, University of Granada, Granada, Spain.
  • Zhu Y; Bioinformatics Unit. GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, PTS Granada, Granada, Spain.
  • Forhan A; Murdoch Children's Research Institute, Parkville, VIC, Australia.
  • Sammallahti S; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
  • Everson TM; Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, MI, USA.
  • Chen J; Department of Medical Microbiology and Immunology, MIND Institute, Genome Center, University of California, Davis, CA, USA.
  • Michels KB; Université de Paris, Centre for Research in Epidemiology and Statistics (CRESS), INSERM, INRAE, Paris, France.
  • Belmonte T; Department of Child and Adolescent Psychiatry and Psychology, Erasmus MC, Rotterdam, The Netherlands.
  • Carmona-Sáez P; Gangarosa Department of Environmental Health, Rollins School of Public Health at Emory University, Atlanta, GA, USA.
  • Halliday J; Department of Epidemiology, Rollins School of Public health at Emory University, Atlanta, GA, USA.
  • Daniele Fallin M; Department of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
  • LaSalle JM; Department of Epidemiology, Fielding School of Public Health, University of California, Los Angeles, CA, USA.
  • Tost J; Institute for Prevention and Cancer Epidemiology, Faculty of Medicine and Medical Center, University of Freiburg, Freiburg, Germany.
  • Czamara D; Health Research Institute of Asturias, ISPA and Biomedical Research and Innovation Institute of Cadiz (INiBICA), Research Unit, Puerta del Mar University Hospital, Cadiz, Spain.
  • Fernández MF; Department of Statistics and Operations Research, University of Granada, Granada, Spain.
  • Gómez-Martín A; Bioinformatics Unit. GENYO, Centre for Genomics and Oncological Research: Pfizer, University of Granada, Andalusian Regional Government, PTS Granada, Granada, Spain.
  • Craig JM; Murdoch Children's Research Institute, Parkville, VIC, Australia.
  • Gonzalez-Alzaga B; Department of Paediatrics, University of Melbourne, Parkville, VIC, Australia.
  • Schmidt RJ; Wendy Klag Center for Autism and Developmental Disabilities, Bloomberg School of Public Health, Johns Hopkins University, Baltimore, MD, USA.
  • Dou JF; Department of Medical Microbiology and Immunology, MIND Institute, Genome Center, University of California, Davis, CA, USA.
  • Muggli E; Laboratory for Epigenetics & Environment, Centre National de Recherche en Génomique Humaine, CEA-Institut de Biologie François Jacob, Evry, France.
  • Lacasaña M; Max-Planck-Institute of Psychiatry, Department of Translational Research in Psychiatry, Munich, Germany.
  • Vrijheid M; University of Granada, Center for Biomedical Research (CIBM), Granada, Spain.
  • Marsit CJ; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
  • Karagas MR; CIBER of Epidemiology and Public Health (CIBERESP), Madrid, Spain.
  • Räikkönen K; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
  • Bouchard L; Andalusian School of Public Health (EASP), Granada, Spain.
  • Heude B; Murdoch Children's Research Institute, Parkville, VIC, Australia.
  • Santa-Marina L; Deakin University, IMPACT - the Institute for Mental and Physical Health and Clinical Translation, School of Medicine, Geelong, Australia.
  • Bustamante M; Instituto de Investigación Biosanitaria ibs.GRANADA, Granada, Spain.
  • Hivert MF; Andalusian School of Public Health (EASP), Granada, Spain.
  • Bilbao JR; Department of Public Health Sciences and the MIND Institute, University of California Davis School of Medicine, Davis, CA, USA.
Commun Biol ; 5(1): 1313, 2022 11 30.
Article em En | MEDLINE | ID: mdl-36446949
ABSTRACT
Higher maternal pre-pregnancy body mass index (ppBMI) is associated with increased neonatal morbidity, as well as with pregnancy complications and metabolic outcomes in offspring later in life. The placenta is a key organ in fetal development and has been proposed to act as a mediator between the mother and different health outcomes in children. The overall aim of the present work is to investigate the association of ppBMI with epigenome-wide placental DNA methylation (DNAm) in 10 studies from the PACE consortium, amounting to 2631 mother-child pairs. We identify 27 CpG sites at which we observe placental DNAm variations of up to 2.0% per 10 ppBMI-unit. The CpGs that are differentially methylated in placenta do not overlap with CpGs identified in previous studies in cord blood DNAm related to ppBMI. Many of the identified CpGs are located in open sea regions, are often close to obesity-related genes such as GPX1 and LGR4 and altogether, are enriched in cancer and oxidative stress pathways. Our findings suggest that placental DNAm could be one of the mechanisms by which maternal obesity is associated with metabolic health outcomes in newborns and children, although further studies will be needed in order to corroborate these findings.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Metilação de DNA Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Child / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Placenta / Metilação de DNA Tipo de estudo: Prognostic_studies / Systematic_reviews Limite: Child / Female / Humans / Newborn / Pregnancy Idioma: En Ano de publicação: 2022 Tipo de documento: Article