Tumor- and metastasis-promoting roles of miR-488 inhibition via HULC enhancement and EZH2-mediated p53 repression in gastric cancer.

Yang, Dejun; Shi, Mengyao; You, Qing; Zhang, Yu; Hu, Zunqi; Xu, Jiapeng; Cai, Qingping; Zhu, Zhenxin

Yang, Dejun; Shi, Mengyao; You, Qing; Zhang, Yu; Hu, Zunqi; Xu, Jiapeng; Cai, Qingping; Zhu, Zhenxin.

Afiliação

Yang D; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China.
Shi M; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China.
You Q; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China.
Zhang Y; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China.
Hu Z; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China.
Xu J; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China.
Cai Q; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China. caiqingping@smmu.edu.cn.
Zhu Z; Department of Gastrointestinal Surgery, Second Affiliated Hospital of Naval Medical University, Huangpu District, No. 415 Fengyang Road, Shanghai, 200003, China. zhuzhenxin@smmu.edu.cn.

Cell Biol Toxicol ; 39(4): 1341-1358, 2023 08.

Article em En | MEDLINE | ID: mdl-36449143

Assuntos

MicroRNAs; Neoplasias Gástricas; Animais; Humanos; Camundongos; Carcinogênese; Linhagem Celular Tumoral; Transformação Celular Neoplásica; Proteína Potenciadora do Homólogo 2 de Zeste/genética; Proteína Potenciadora do Homólogo 2 de Zeste/metabolismo; Histonas; Neoplasias Hepáticas/genética; MicroRNAs/genética; MicroRNAs/metabolismo; Neoplasias Gástricas/metabolismo; Proteína Supressora de Tumor p53/genética

Palavras-chave

EZH2; Gastric cancer; HULC; Metastasis; microRNA-488; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Gástricas / MicroRNAs Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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