Technical approaches and challenges to study AMPA receptors in oligodendrocyte lineage cells: Past, present, and future.
Glia
; 71(4): 819-847, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36453615
ABSTRACT
Receptors for α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPARs) are ligand-gated ionotropic receptors for glutamate that is a major excitatory neurotransmitter in the central nervous system. AMPARs are located at postsynaptic sites of neuronal synapses where they mediate fast synaptic signaling and synaptic plasticity. Remarkably, AMPARs are also expressed by glial cells. Their expression by the oligodendrocyte (OL) lineage cells is of special interest because AMPARs mediate fast synaptic communication between neurons and oligodendrocyte progenitor cells (OPCs), modulate proliferation and differentiation of OPCs, and may also be involved in regulation of myelination. On the other hand, during pathological conditions, AMPARs may mediate damage of the OL lineage cells. In the present review, we focus on the technical approaches that have been used to study AMPARs in the OL lineage cells, and discuss future perspectives of AMPAR research in these glial cells.
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Base de dados:
MEDLINE
Assunto principal:
Receptores de AMPA
/
Neurônios
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article