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Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3Kα.
Hanan, Emily J; Braun, Marie-Gabrielle; Heald, Robert A; MacLeod, Calum; Chan, Connie; Clausen, Saundra; Edgar, Kyle A; Eigenbrot, Charles; Elliott, Richard; Endres, Nicholas; Friedman, Lori S; Gogol, Emily; Gu, Xiao-Hui; Thibodeau, Rebecca Hong; Jackson, Philip S; Kiefer, James R; Knight, Jamie D; Nannini, Michelle; Narukulla, Raman; Pace, Amanda; Pang, Jodie; Purkey, Hans E; Salphati, Laurent; Sampath, Deepak; Schmidt, Stephen; Sideris, Steve; Song, Kyung; Sujatha-Bhaskar, Swathi; Ultsch, Mark; Wallweber, Heidi; Xin, Jianfeng; Yeap, SiewKuen; Young, Amy; Zhong, Yu; Staben, Steven T.
Afiliação
  • Hanan EJ; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Braun MG; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Heald RA; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.
  • MacLeod C; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.
  • Chan C; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Clausen S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Edgar KA; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Eigenbrot C; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Elliott R; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.
  • Endres N; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Friedman LS; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Gogol E; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Gu XH; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Thibodeau RH; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Jackson PS; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.
  • Kiefer JR; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Knight JD; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.
  • Nannini M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Narukulla R; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.
  • Pace A; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Pang J; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Purkey HE; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Salphati L; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Sampath D; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Schmidt S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Sideris S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Song K; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Sujatha-Bhaskar S; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Ultsch M; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Wallweber H; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Xin J; Pharmaron Beijing Co., Ltd, No. 6 Taihe Road, BDA, Beijing 100176, P. R. China.
  • Yeap S; Early Discovery Charles River, 7/8 Spire Green Centre, Flex Meadow, Harlow, Essex CM19 5TR, U.K.
  • Young A; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Zhong Y; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
  • Staben ST; Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States.
J Med Chem ; 65(24): 16589-16621, 2022 12 22.
Article em En | MEDLINE | ID: mdl-36455032
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Fosfatidilinositol 3-Quinases Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Fosfatidilinositol 3-Quinases Limite: Female / Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article