Microfluidic-Assisted Production of Gastro-Resistant Active-Targeted Diatomite Nanoparticles for the Local Release of Galunisertib in Metastatic Colorectal Cancer Cells.

Tramontano, Chiara; Martins, João Pedro; De Stefano, Luca; Kemell, Marianna; Correia, Alexandra; Terracciano, Monica; Borbone, Nicola; Rea, Ilaria; Santos, Hélder A

Tramontano, Chiara; Martins, João Pedro; De Stefano, Luca; Kemell, Marianna; Correia, Alexandra; Terracciano, Monica; Borbone, Nicola; Rea, Ilaria; Santos, Hélder A.

Afiliação

Tramontano C; Institute of Applied Sciences and Intelligent Systems, Unit of Naples, National Research Council, Naples, 80131, Italy.
Martins JP; Department of Pharmacy, University of Naples Federico II, Naples, 80131, Italy.
De Stefano L; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
Kemell M; Institute of Applied Sciences and Intelligent Systems, Unit of Naples, National Research Council, Naples, 80131, Italy.
Correia A; Department of Chemistry, University of Helsinki, Helsinki, FI-00014, Finland.
Terracciano M; Drug Research Program, Division of Pharmaceutical Chemistry and Technology, Faculty of Pharmacy, University of Helsinki, Helsinki, FI-00014, Finland.
Borbone N; Department of Pharmacy, University of Naples Federico II, Naples, 80131, Italy.
Rea I; Department of Pharmacy, University of Naples Federico II, Naples, 80131, Italy.
Santos HA; Institute of Applied Sciences and Intelligent Systems, Unit of Naples, National Research Council, Naples, 80131, Italy.

Adv Healthc Mater ; 12(6): e2202672, 2023 01.

Article em En | MEDLINE | ID: mdl-36459471

Assuntos

Neoplasias do Colo; Nanopartículas; Humanos; Células CACO-2; Microfluídica/métodos; Neoplasias do Colo/tratamento farmacológico; Nanopartículas/química; Preparações Farmacêuticas; Estômago; Sistemas de Liberação de Medicamentos/métodos

Palavras-chave

colorectal cancer; diatomite nanoparticles; galunisertib; microfluidics; oral drug delivery

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Colo / Nanopartículas Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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