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Discovery of orally active 1,4,5,6,8-pentaazaacenaphthylens as novel, selective, and potent covalent BTK inhibitors for the treatment of rheumatoid arthritis.
Fang, Xiaobao; Liu, Chunxiao; Zhang, Kun; Yang, Wanping; Wu, Zewen; Shen, Shige; Ma, Yule; Lu, Xun; Chen, Yadong; Lu, Tao; Hu, Qinghua; Jiang, Yulei.
Afiliação
  • Fang X; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Liu C; School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Zhang K; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Yang W; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Wu Z; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Shen S; School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Ma Y; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Lu X; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China.
  • Chen Y; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: ydchen@cpu.edu.cn.
  • Lu T; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China; State Key Laboratory of Natural Medicines, China Pharmaceutical University, 24 Tongjiaxiang, Nanjing, 210009, PR China. Electronic address: lutao@cpu.edu.cn.
  • Hu Q; School of Pharmacy, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: huqh@cpu.edu.cn.
  • Jiang Y; School of Science, China Pharmaceutical University, 639 Longmian Avenue, Nanjing, 211198, PR China. Electronic address: jiangyulei@cpu.edu.cn.
Eur J Med Chem ; 246: 114940, 2023 Jan 15.
Article em En | MEDLINE | ID: mdl-36462441
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Desenho de Fármacos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Artrite Reumatoide / Desenho de Fármacos Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article