Inhibition of Rho-kinase ameliorates decreased spine density in the medial prefrontal cortex and methamphetamine-induced cognitive dysfunction in mice carrying schizophrenia-associated mutations of the Arhgap10 gene.

Tanaka, Rinako; Liao, Jingzhu; Hada, Kazuhiro; Mori, Daisuke; Nagai, Taku; Matsuzaki, Tetsuo; Nabeshima, Toshitaka; Kaibuchi, Kozo; Ozaki, Norio; Mizoguchi, Hiroyuki; Yamada, Kiyofumi

Tanaka, Rinako; Liao, Jingzhu; Hada, Kazuhiro; Mori, Daisuke; Nagai, Taku; Matsuzaki, Tetsuo; Nabeshima, Toshitaka; Kaibuchi, Kozo; Ozaki, Norio; Mizoguchi, Hiroyuki; Yamada, Kiyofumi.

Afiliação

Tanaka R; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Liao J; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Hada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Mori D; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Nagai T; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan; Division of Behavioral Neuropharmacology, International Center for Brain Science (ICBS), Fujita Health University, Toyoake, Aichi 470-1192, Japan.
Matsuzaki T; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Nabeshima T; Laboratory of Health and Medical Science Innovation, Fujita Health University Graduate School of Health Sciences, Toyoake, Aichi 470-1192, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Aichi 468-0069, Japan.
Kaibuchi K; Department of Cell Pharmacology, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan; International Center for Brain Science, Fujita Health University, Toyoake, Aichi 470-1129, Japan.
Ozaki N; Department of Psychiatry, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Mizoguchi H; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan.
Yamada K; Department of Neuropsychopharmacology and Hospital Pharmacy, Nagoya University Graduate School of Medicine, Nagoya, Aichi 466-8560, Japan; Japanese Drug Organization of Appropriate Use and Research, Nagoya, Aichi 468-0069, Japan. Electronic address: kyamada@med.nagoya-u.ac.jp.

Pharmacol Res ; 187: 106589, 2023 01.

Article em En | MEDLINE | ID: mdl-36462727

Assuntos

Disfunção Cognitiva; Esquizofrenia; Animais; Camundongos; Disfunção Cognitiva/induzido quimicamente; Disfunção Cognitiva/tratamento farmacológico; Disfunção Cognitiva/genética; Mutação; Córtex Pré-Frontal/metabolismo; Inibidores de Proteínas Quinases/farmacologia; Quinases Associadas a rho/metabolismo; Esquizofrenia/induzido quimicamente; Esquizofrenia/tratamento farmacológico; Esquizofrenia/genética

Palavras-chave

C-Fos; CNV; MYPT1; ROCK; Small GTPase; fasudil monohydrochloride salt (PubChem CID: 163751); methamphetamine (PubChem CID: 10836)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Esquizofrenia / Disfunção Cognitiva Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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