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Bioactive Arylnaphthalide Lignans from Justicia depauperata.
Tchegnitegni Toussie, Billy; Nguengang, Ruland Tchuinkeu; Mawabo, Isabelle Kamga; Teponno, Rémy Bertrand; Kezetas Bankeu, Jean Jules; Chouna, Jean Rodolphe; Nkenfou, Celine Ngeufeu; Tapondjou, Léon Azefack; Sewald, Norbert; Lenta, Bruno Ndjakou.
Afiliação
  • Tchegnitegni Toussie B; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Nguengang RT; Organic and Bioorganic Chemistry, Faculty of Chemistry, University of Bielefeld, D-33501 Bielefeld, Germany.
  • Mawabo IK; Department of Chemistry, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon.
  • Teponno RB; Department of Organic Chemistry, Faculty of Science, University of Yaoundé I, P.O. Box 812, Yaoundé, Cameroon.
  • Kezetas Bankeu JJ; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Chouna JR; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Nkenfou CN; Department of Chemistry, Faculty of Science, The University of Bamenda, P.O. Box 39, Bambili, Cameroon.
  • Tapondjou LA; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
  • Sewald N; Department of Biology, Higher Teacher Training College, University of Yaoundé I, P.O. Box 47, Yaoundé, Cameroon.
  • Lenta BN; Department of Chemistry, Faculty of Science, University of Dschang, P.O. Box 67, Dschang, Cameroon.
J Nat Prod ; 85(12): 2731-2739, 2022 12 23.
Article em En | MEDLINE | ID: mdl-36469853
Eleven previously undescribed arylnaphthalide lignans (1-11) together with seven known compounds were isolated from the whole plant of Justicia depauperata. The structures of 1-11 were elucidated by spectroscopic analysis and mass spectrometry. Compounds 6 (IC50 = 4.1 µM) and 9 (IC50 = 9.5 µM) displayed cytotoxic activity against the KB-3-1 cervical carcinoma cell line. This report provides an insight into the conformational equilibria occurring in the arylnaphthalide lignan constituents of this plant.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Lignanas / Acanthaceae / Justicia Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Medicamentos de Ervas Chinesas / Lignanas / Acanthaceae / Justicia Idioma: En Ano de publicação: 2022 Tipo de documento: Article