Your browser doesn't support javascript.
loading
Synovial fluid pH sensor for early detection of prosthetic hip infections.
Wijayaratna, Uthpala; Kiridena, Sachindra; Adams, John D; Behrend, Caleb J; Anker, Jeffrey N.
Afiliação
  • Wijayaratna U; Department of Chemistry, Clemson University, 102 BRC, 105 Collings St., Clemson, SC 29634, USA.
  • Kiridena S; Department of Chemistry, Clemson University, 102 BRC, 105 Collings St., Clemson, SC 29634, USA.
  • Adams JD; Prisma Health-Upstate, Department of Orthopedic Surgery, Second Floor Support Tower, 701 Grove Road, Greenville, SC 29605, USA.
  • Behrend CJ; OrthoArizona, 1675 E. Melrose St., Gilbert, AZ 85297, USA.
  • Anker JN; Departments of Chemistry and BioEngineering, and Center for Optical Materials Science and Engineering Technology (COMSET), Clemson University, 102 BRC, 105 Collings St., Clemson, SC 29634, USA.
Adv Funct Mater ; 31(37)2021 Sep 09.
Article em En | MEDLINE | ID: mdl-36478668
We describe an implantable sensor developed to measure synovial fluid pH for noninvasive early detection and monitoring of hip infections using standard-of-care plain radiography. The sensor was made of a pH responsive polyacrylic acid-based hydrogel, which expands at high pH and contracts at low pH. A radiodense tantalum bead and a tungsten wire were embedded in the two ends of the hydrogel in order to monitor the change in length of the hydrogel sensor in response to pH via plain radiography. The effective pKa of the hydrogel-based pH sensor was 5.6 with a sensitivity of 3 mm/pH unit between pH 4 and 8. The sensor showed a linear response and reversibility in the physiologically relevant pH range of pH 6.5 and 7.5 in both buffer and bovine synovial fluid solutions with a 30-minute time constant. The sensor was attached to an explanted prosthetic hip and the pH response determined from the X-ray images by measuring the length between the tantalum bead and the radiopaque wire. Therefore, the developed sensor would enable noninvasive detection and studying of implant hip infection using plain radiography.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Diagnostic_studies / Screening_studies Idioma: En Ano de publicação: 2021 Tipo de documento: Article