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SARS-COV-2 infections in inborn errors of immunity: A single center study.
Cousins, Kimberley; DeFelice, Nicholas; Jeong, Stephanie; Feng, Jin; Lee, Ashley Sang Eun; Rotella, Karina; Sanchez, David; Jaber, Faris; Agarwal, Shradha; Ho, Hsi-En; Cunningham-Rundles, Charlotte.
Afiliação
  • Cousins K; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • DeFelice N; The Division of Environmental Medicine and Public Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Jeong S; Institute of Exposomic Research, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Feng J; Arnold Institute for Global Health, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Lee ASE; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Rotella K; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Sanchez D; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Jaber F; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Agarwal S; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Ho HE; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
  • Cunningham-Rundles C; The Division of Clinical Immunology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, NY, United States.
Front Immunol ; 13: 1035571, 2022.
Article em En | MEDLINE | ID: mdl-36479106
ABSTRACT
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). One of the main topics of conversation in these past months in the world of immunology has been the issue of how patients with immune defects will fare if they contract this infection. To date there has been limited data on larger cohorts of patients with Inborn Errors of Immunity (IEI) diagnosed with COVID-19. Here, we review the data of COVID-19 infections in a single center cohort of 113 patients from the Mount Sinai Immunodeficiency program, who had 132 infections between January 2020 and June 2022. This included 56 males and 57 females, age range 2 - 84 (median 42). The mortality rate was 3%. Comparison between admitted patients revealed a significantly increased risk of hospitalization amongst the unvaccinated patients, 4% vaccinated vs 40% unvaccinated; odds ratio 15.0 (95% CI 4.2 - 53.4; p <0.00001). Additionally, COVID anti-spike antibody levels, determined in 36 of these patients post vaccination and before infection, were highly variable.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: COVID-19 Limite: Adolescent / Adult / Aged / Aged80 / Child / Child, preschool / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 2022 Tipo de documento: Article