Your browser doesn't support javascript.
loading
Dietary restriction in senolysis and prevention and treatment of disease.
Aminzadeh-Gohari, Sepideh; Kofler, Barbara; Herzog, Chiara.
Afiliação
  • Aminzadeh-Gohari S; Research Program for Receptor Biochemistry and Tumor Metabollism, Department of Pediatrics, University Hospital of the Paracelsus Medical University, Salzburg, Austria.
  • Kofler B; European Translational Oncology Prevention and Screening Institute, Universität Innsbruck, Innsbruck, Austria.
  • Herzog C; Research Institute for Biomedical Ageing, Universität Innsbruck, Innsbruck, Austria.
Crit Rev Food Sci Nutr ; : 1-27, 2022 Dec 09.
Article em En | MEDLINE | ID: mdl-36484738
ABSTRACT
Aging represents a key risk factor for a plethora of diseases. Targeting detrimental processes which occur during aging, especially before onset of age-related disease, could provide drastic improvements in healthspan. There is increasing evidence that dietary restriction (DR), including caloric restriction, fasting, or fasting-mimicking diets, extend both lifespan and healthspan. This has sparked interest in the use of dietary regimens as a non-pharmacological means to slow aging and prevent disease. Here, we review the current evidence on the molecular mechanisms underlying DR-induced health improvements, including removal of senescent cells, metabolic reprogramming, and epigenetic rejuvenation.
Palavras-chave

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Risk_factors_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article