Domestic dog lineages reveal genetic drivers of behavioral diversification.
Cell
; 185(25): 4737-4755.e18, 2022 Dec 08.
Article
em En
| MEDLINE
| ID: mdl-36493753
ABSTRACT
Selective breeding of domestic dogs has generated diverse breeds often optimized for performing specialized tasks. Despite the heritability of breed-typical behavioral traits, identification of causal loci has proven challenging due to the complexity of canine population structure. We overcome longstanding difficulties in identifying genetic drivers of canine behavior by developing a framework for understanding relationships between breeds and the behaviors that define them, utilizing genetic data for over 4,000 domestic, semi-feral, and wild canids and behavioral survey data for over 46,000 dogs. We identify ten major canine genetic lineages and their behavioral correlates and show that breed diversification is predominantly driven by non-coding regulatory variation. We determine that lineage-associated genes converge in neurodevelopmental co-expression networks, identifying a sheepdog-associated enrichment for interrelated axon guidance functions. This work presents a scaffold for canine diversification that positions the domestic dog as an unparalleled system for revealing the genetic origins of behavioral diversity.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Comportamento Animal
/
Cães
Limite:
Animals
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article