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Cytokine profiles are associated with prolonged hematologic toxicities after B-cell maturation antigen targeted chimeric antigen receptor-T-cell therapy.
Wang, Linqin; Hong, Ruimin; Zhou, Linghui; Wang, Yiyun; Lv, Yuqi; Ni, Fang; Zhang, Mingming; Zhao, Houli; Ding, Shuyi; Chang, Alex H; Xu, Huijun; Hu, Yongxian; Wei, Guoqing; Huang, He.
Afiliação
  • Wang L; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Hong R; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Zhou L; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Wang Y; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Lv Y; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Ni F; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Zhang M; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Zhao H; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Ding S; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China.
  • Chang AH; Shanghai YaKe Biotechnology Ltd.; Clinical Translational Research Center, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, China.
  • Xu H; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Hu Y; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Wei G; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
  • Huang H; Bone Marrow Transplantation Center, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China;; Liangzhu Laboratory, Zhejiang University Medical Center, Hangzhou, China;; Institute of Hematology, Zhejiang University, Hangzhou, China;; Zhejiang Province Engineering Labor
Cytotherapy ; 25(2): 192-201, 2023 02.
Article em En | MEDLINE | ID: mdl-36496302
ABSTRACT
BACKGROUND

AIMS:

The considerable efficacy of B-cell maturation antigen-targeted chimeric antigen receptor (CAR)-T-cell therapy has been extensively demonstrated in the treatment of relapsed or refractory multiple myeloma. Nevertheless, in clinical practice, prolonged hematologic toxicity (PHT) extends hospital stay and impairs long-term survival.

METHODS:

This retrospective study reviewed 99 patients with relapsed or refractory multiple myeloma who underwent B-cell maturation antigen CAR-T-cell therapy at our institution between April 2018 and September 2021 (ChiCTR1800017404).

RESULTS:

Among 93 evaluable patients, the incidence of prolonged hematologic toxicities was high after CAR-T-cell infusion, including 38.71% (36/93) of patients with prolonged neutropenia, 22.58% (21/93) with prolonged anemia and 59.14% (55/93) with prolonged thrombocytopenia. In addition, 9.68% (9/93) of patients experienced prolonged pancytopenia. Our multivariate analyses identified that cytokine profiles were independent risk factors for PHTs, whereas a sufficient baseline hematopoietic function and high CD4/CD8 ratio of CAR-T cells were protective factors for PHTs after CAR-T-cell infusion. Subgroup analyses found that the kinetics of post-CAR-T hematologic parameters were primarily determined by the collective effects of cytokine release syndrome and baseline hematopoietic functions, and showed influential weights for the three lineages.

CONCLUSIONS:

Our findings improve the understanding of the impact of cytokines on hematopoietic functions, which could contribute to the mechanism investigation and exploration of potential intervention strategies.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Mieloma Múltiplo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Receptores de Antígenos Quiméricos / Mieloma Múltiplo Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article