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Cognitive Impairment Mediates the Association between Dietary Inflammation and Depressive Symptoms in the Elderly.
Sun, Mengzi; Wang, Ling; Hu, Yueyang; Wang, Xuhan; Yan, Shoumeng; Guo, Yinpei; Li, Jing; Xie, Zechun; Li, Bo.
Afiliação
  • Sun M; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
  • Wang L; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
  • Hu Y; Department of Social Medicine and Health Management, School of Public Health, Jilin University, Changchun 130012, China.
  • Wang X; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
  • Yan S; School of Nursing, Jilin University, Changchun 130021, China.
  • Guo Y; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
  • Li J; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
  • Xie Z; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
  • Li B; Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun 130021, China.
Nutrients ; 14(23)2022 Dec 02.
Article em En | MEDLINE | ID: mdl-36501149
The underlying mechanism in both cognitive impairment and depression was chronic inflammation, which could be reflected by the dietary inflammatory index (DII). However, the effect of cognitive impairment on the association between DII and depression was not clear. Therefore, in this study, we hypothesized that cognitive impairment could mediate the association between dietary inflammation and depressive symptoms. A total of 2550 participants aged ≥60 from the National Health and Nutrition Examination Survey (NHANES) in 2011-2014 were involved in the serial, cross-sectional study. Proinflammatory and anti-inflammatory diets were measured by DII. Cognitive impairment was measured by four dimensions, CERAD-immediate, CERAN-delayed, animal fluency test, and DSST. Depressive symptoms were measured by PHQ-9 scores. We found that a proinflammatory diet and cognitive impairment were both risk factors for depressive symptoms. An interaction between an inflammatory diet and cognitive impairment was detected (P-interaction = 0.060). In addition, all four dimensions of cognition mediated the association between DII and depressive symptom scores. Part of the association between DII and depressive symptoms scores could be explained by different dimensions of cognitive function, and the proportion of mediation ranged from 10.0% to 36.7%. In conclusion, cognitive impairment levels partly mediated the association between DII and depressive symptoms.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dieta / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dieta / Disfunção Cognitiva Tipo de estudo: Diagnostic_studies / Etiology_studies / Observational_studies / Prevalence_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article