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Phenotype-based screening rediscovered benzopyran-embedded microtubule inhibitors as anti-neuroinflammatory agents by modulating the tubulin-p65 interaction.
Yim, Junhyeong; Lee, Jaeseok; Yi, Sihyeong; Koo, Ja Young; Oh, Sangmi; Park, Hankum; Kim, Seong Soon; Bae, Myung Ae; Park, Jongmin; Park, Seung Bum.
Afiliação
  • Yim J; Department of Biophysics and Chemical Biology, Seoul National University, Seoul, 08826, Korea.
  • Lee J; Department of Chemistry, Kangwon National University, Chuncheon, 24341, Korea.
  • Yi S; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea.
  • Koo JY; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea.
  • Oh S; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea.
  • Park H; CRI Center for Chemical Proteomics, Department of Chemistry, Seoul National University, Seoul, 08826, Korea.
  • Kim SS; Department of Dental Sciences, School of Dentistry and Dental Research Institute, Seoul National University, Seoul, 08826, Korea.
  • Bae MA; Bio Platform Technology Research Center, Korea Research Institute of Chemical Technology, Daejeon, 34114, Korea.
  • Park J; Bio Platform Technology Research Center, Korea Research Institute of Chemical Technology, Daejeon, 34114, Korea.
  • Park SB; Department of Medicinal Chemistry and Pharmacology, University of Science & Technology, Daejeon, 34114, Korea.
Exp Mol Med ; 54(12): 2200-2209, 2022 12.
Article em En | MEDLINE | ID: mdl-36509830
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tubulina (Proteína) / Moduladores de Tubulina Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Tubulina (Proteína) / Moduladores de Tubulina Tipo de estudo: Diagnostic_studies / Prognostic_studies / Screening_studies Limite: Animals Idioma: En Ano de publicação: 2022 Tipo de documento: Article