G-rich motifs within phosphorothioate-based antisense oligonucleotides (ASOs) drive activation of FXN expression through indirect effects.

Wang, Feng; Calvo-Roitberg, Ezequiel; Rembetsy-Brown, Julia M; Fang, Minggang; Sousa, Jacquelyn; Kartje, Zachary J; Krishnamurthy, Pranathi Meda; Lee, Jonathan; Green, Michael R; Pai, Athma A; Watts, Jonathan K

Wang, Feng; Calvo-Roitberg, Ezequiel; Rembetsy-Brown, Julia M; Fang, Minggang; Sousa, Jacquelyn; Kartje, Zachary J; Krishnamurthy, Pranathi Meda; Lee, Jonathan; Green, Michael R; Pai, Athma A; Watts, Jonathan K.

Afiliação

Wang F; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Calvo-Roitberg E; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Rembetsy-Brown JM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Fang M; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Sousa J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Kartje ZJ; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Krishnamurthy PM; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Lee J; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Green MR; Department of Molecular, Cell and Cancer Biology, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Pai AA; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.
Watts JK; RNA Therapeutics Institute, University of Massachusetts Chan Medical School, Worcester, MA, 01605, USA.

Nucleic Acids Res ; 50(22): 12657-12673, 2022 12 09.

Article em En | MEDLINE | ID: mdl-36511872

Assuntos

Ataxia de Friedreich; Regulação da Expressão Gênica; Oligonucleotídeos Antissenso; Humanos; Ataxia de Friedreich/genética; Proteínas de Ligação ao Ferro/genética; Proteínas de Ligação ao Ferro/metabolismo; Oligonucleotídeos Antissenso/genética; Oligonucleotídeos Antissenso/farmacologia; Oligonucleotídeos Antissenso/metabolismo; RNA Mensageiro/metabolismo; Células Cultivadas; Proteínas de Ligação a DNA/genética; Proteínas de Ligação a DNA/metabolismo; Frataxina

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ataxia de Friedreich / Regulação da Expressão Gênica / Oligonucleotídeos Antissenso Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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