Cell-Based Screening for New PARP Inhibitors Utilizing PARG-Mutated Mouse Embryonic Stem Cells.

Karpova, Yaroslava; Guo, Danping; Tulin, Alexei V

Karpova, Yaroslava; Guo, Danping; Tulin, Alexei V.

Afiliação

Karpova Y; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.
Guo D; Koltzov Institute of Developmental Biology of Russian Academy of Sciences, Moscow, Russia.
Tulin AV; Department of Biomedical Sciences, School of Medicine and Health Sciences, University of North Dakota, Grand Forks, ND, USA.

Methods Mol Biol ; 2609: 375-385, 2023.

Article em En | MEDLINE | ID: mdl-36515848

Assuntos

Antineoplásicos; Neoplasias; Animais; Camundongos; Inibidores de Poli(ADP-Ribose) Polimerases/farmacologia; Células-Tronco Embrionárias Murinas; Glicosídeo Hidrolases

Palavras-chave

Inhibitor screening; Mouse ES cells; PARG 29b; PARG hypomorph; PARG knockout; PARP; PARP inhibitors; Poly(ADP-ribosyl)ation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias / Antineoplásicos Tipo de estudo: Diagnostic_studies / Screening_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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