GDF15 negatively regulates chemosensitivity via TGFBR2-AKT pathway-dependent metabolism in esophageal squamous cell carcinoma.

Du, Yingxi; Ma, Yarui; Zhu, Qing; Fu, Yong; Li, Yutong; Zhang, Ying; Li, Mo; Feng, Feiyue; Yuan, Peng; Wang, Xiaobing

Du, Yingxi; Ma, Yarui; Zhu, Qing; Fu, Yong; Li, Yutong; Zhang, Ying; Li, Mo; Feng, Feiyue; Yuan, Peng; Wang, Xiaobing.

Afiliação

Du Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Ma Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Zhu Q; Department of Clinical Laboratory, Beijing Friendship Hospital, Capital Medical University, Beijing, 100050, China.
Fu Y; Township Health Center in Tanggou Town, Wuhu, 24100, China.
Li Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Zhang Y; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Li M; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China.
Feng F; Thoracic Surgery Department, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. feiyuefeng@aliyun.com.
Yuan P; Department of VIP Medical Services, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. yuanpeng01@hotmail.com.
Wang X; State Key Laboratory of Molecular Oncology, National Cancer Center/National Clinical Research Center for Cancer/Cancer Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100021, China. wangxb@cicams.ac.cn.

Front Med ; 17(1): 119-131, 2023 Feb.

Article em En | MEDLINE | ID: mdl-36525138

Assuntos

Carcinoma de Células Escamosas; Neoplasias Esofágicas; Carcinoma de Células Escamosas do Esôfago; Humanos; Carcinoma de Células Escamosas do Esôfago/tratamento farmacológico; Cisplatino/farmacologia; Cisplatino/metabolismo; Neoplasias Esofágicas/tratamento farmacológico; Neoplasias Esofágicas/genética; Neoplasias Esofágicas/metabolismo; Proteínas Proto-Oncogênicas c-akt/metabolismo; Carcinoma de Células Escamosas/tratamento farmacológico; Carcinoma de Células Escamosas/genética; Fator 15 de Diferenciação de Crescimento/metabolismo; Fator 15 de Diferenciação de Crescimento/farmacologia; Fator 15 de Diferenciação de Crescimento/uso terapêutico; Receptor do Fator de Crescimento Transformador beta Tipo II/metabolismo; Receptor do Fator de Crescimento Transformador beta Tipo II/uso terapêutico; Linhagem Celular Tumoral; Proliferação de Células; Regulação Neoplásica da Expressão Gênica

Palavras-chave

AKT; GDF15; TGFBR2; cellular metabolism; chemoresistance; esophageal squamous cell carcinoma

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Esofágicas / Carcinoma de Células Escamosas / Carcinoma de Células Escamosas do Esôfago Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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