Osteopontin (OPN)/SPP1: from its biochemistry to biological functions in the innate immune system and the central nervous system (CNS).
Int Immunol
; 35(4): 171-180, 2023 04 04.
Article
em En
| MEDLINE
| ID: mdl-36525591
ABSTRACT
Osteopontin (OPN) is a multifunctional protein, initially identified in osteosarcoma cells with its role of mediating osteoblast adhesion. Later studies revealed that OPN is associated with many inflammatory conditions caused by infections, allergic responses, autoimmunity and tissue damage. Many cell types in the peripheral immune system express OPN with various functions, which could be beneficial or detrimental. Also, more recent studies demonstrated that OPN is highly expressed in the central nervous system (CNS), particularly in microglia during CNS diseases and development. However, understanding of mechanisms underlying OPN's functions in the CNS is still limited. In this review, we focus on peripheral myeloid cells and CNS-resident cells to discuss the expression and functions of OPN.
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Base de dados:
MEDLINE
Assunto principal:
Sistema Nervoso Central
/
Osteopontina
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article