CNS tumor with BCOR internal tandem duplication.

Hazrati, Lili-Naz; Monajemzadeh, Maryam; Habibi, Zohreh; Moeini, Bahar; Safavi, Moeinadin

Hazrati, Lili-Naz; Monajemzadeh, Maryam; Habibi, Zohreh; Moeini, Bahar; Safavi, Moeinadin.

Afiliação

Hazrati LN; Department of Pathology, University of Toronto, University Health Network, Toronto, ON, Canada.
Monajemzadeh M; The Hospital for Sick Children, Toronto, Canada.
Habibi Z; Pathology Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Moeini B; Neurosurgery Department, Children Medical Center, Tehran University of Medical Sciences, Tehran, Iran.
Safavi M; Department of Radiation Oncology, MAHAK Pediatric Cancer Treatment and Research Center, Tehran, Iran.

Childs Nerv Syst ; 39(2): 321-324, 2023 02.

Article em En | MEDLINE | ID: mdl-36527465

RESUMO

CNS tumor with BCOR internal tandem duplication is a recently proposed malignant tumor. The patient was an 18-month-old boy with torticollis and vomiting due to cerebellar hemispheric mass with extension to cerebellopontine angle and foramen magnum. Histopathologic examination of the tumor showed a moderately cellular tumor with microcystic formation, myxoid change, and atypical rosettes resembling Homer Wright rosettes. Illumina TruSight RNA Pan-Cancer NGS of the tumor genome revealed BCOR gene exon 15 internal tandem duplications.

Assuntos

Neoplasias do Sistema Nervoso Central; Cistos; Humanos; Lactente; Masculino; Biomarcadores Tumorais/genética; Neoplasias do Sistema Nervoso Central/genética; Éxons; Proteínas Proto-Oncogênicas/genética; Proteínas Repressoras/genética

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias do Sistema Nervoso Central / Cistos Limite: Humans / Infant / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google