Synthesis, Antitumor Activity, and <i>In Silico</i> Drug Design of New Thieno[2,3-<i>d</i>]Pyrimidine-4-One Derivatives as Nonclassical Lipophilic Dihydrofolate Reductase Inhibitors.

Abdelaziz, Ola A; El Husseiny, Walaa M; Selim, Khalid B; Eisa, Hassan M

Synthesis, Antitumor Activity, and In Silico Drug Design of New Thieno[2,3-d]Pyrimidine-4-One Derivatives as Nonclassical Lipophilic Dihydrofolate Reductase Inhibitors.

Abdelaziz, Ola A; El Husseiny, Walaa M; Selim, Khalid B; Eisa, Hassan M.

Afiliação

Abdelaziz OA; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
El Husseiny WM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Selim KB; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.
Eisa HM; Department of Pharmaceutical Organic Chemistry, Faculty of Pharmacy, Mansoura University, Mansoura 35516, Egypt.

ACS Omega ; 7(49): 45455-45468, 2022 Dec 13.

Article em En | MEDLINE | ID: mdl-36530275

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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2022 Tipo de documento: Article