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The 2019-2020 Dengue Fever Epidemic: Genomic Markers Indicating Severity in Dominican Republic Children.
Simpson, Brittany N; Mejía Sang, Miguel E; Collado Puello, Yonairy; Diaz Brockmans, Elvira J; Díaz Soto, María F; Rivera Defilló, Stephanie M; Taveras Cruz, Karla M; Santiago Pérez, Javier O; Husami, Ammar; Day, Melissa E; Pilipenko, Valentina; Mena, Rafael; Mota, Cesár; Hostetter, Margaret K; Muglia, Louis J; Schlaudecker, Elizabeth; Gonzalez Del Rey, Javier; Martin, Lisa J; Prada, Carlos E.
Afiliação
  • Simpson BN; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Mejía Sang ME; Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Collado Puello Y; Instituto Tecnológico de Santo Domingo, School of Medicine, Santo Domingo, Dominican Republic.
  • Diaz Brockmans EJ; Instituto Tecnológico de Santo Domingo, School of Medicine, Santo Domingo, Dominican Republic.
  • Díaz Soto MF; School of Medicine, Universidad Iberamericana (UNIBE), Santo Domingo, Dominican Republic.
  • Rivera Defilló SM; Instituto Tecnológico de Santo Domingo, School of Medicine, Santo Domingo, Dominican Republic.
  • Taveras Cruz KM; Instituto Tecnológico de Santo Domingo, School of Medicine, Santo Domingo, Dominican Republic.
  • Santiago Pérez JO; Instituto Tecnológico de Santo Domingo, School of Medicine, Santo Domingo, Dominican Republic.
  • Husami A; Instituto Tecnológico de Santo Domingo, School of Medicine, Santo Domingo, Dominican Republic.
  • Day ME; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Pilipenko V; Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Mena R; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Mota C; Centro de Obstetricia y Ginecología, Santo Domingo, Dominican Republic.
  • Hostetter MK; Pediatric Emergency Medicine Department, Hospital Infantil Dr. Robert Reid, Santo Domingo, Dominican Republic.
  • Muglia LJ; Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Schlaudecker E; Division of Human Genetics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Gonzalez Del Rey J; Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
  • Martin LJ; Burroughs Welcome Fund, Research Triangle Park, North Carolina, USA.
  • Prada CE; Department of Pediatrics, University of Cincinnati School of Medicine, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, USA.
J Pediatric Infect Dis Soc ; 12(3): 169-172, 2023 Apr 18.
Article em En | MEDLINE | ID: mdl-36537278
ABSTRACT
We performed an observational cohort study to assess associations between genetic factors of dengue fever (DF) severity in children in the Dominican Republic. A total of 488 participants had serologically confirmed DF. We replicated the association between the IFIH1 gene (rs1990760) and severe DF (n = 80/488, p = 0.006) and identified novel associations needing further investigation.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dengue Grave / Dengue Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans País como assunto: Caribe ingles / Dominica / Republica dominicana Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dengue Grave / Dengue Tipo de estudo: Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Child / Humans País como assunto: Caribe ingles / Dominica / Republica dominicana Idioma: En Ano de publicação: 2023 Tipo de documento: Article