The REACT study: design of a randomized phase 3 trial to assess the efficacy and safety of clazosentan for preventing deterioration due to delayed cerebral ischemia after aneurysmal subarachnoid hemorrhage.

Bruder, Nicolas; Higashida, Randall; Santin-Janin, Hugues; Dubois, Cécile; Aldrich, E François; Marr, Angelina; Roux, Sébastien; Mayer, Stephan A

Bruder, Nicolas; Higashida, Randall; Santin-Janin, Hugues; Dubois, Cécile; Aldrich, E François; Marr, Angelina; Roux, Sébastien; Mayer, Stephan A.

Afiliação

Bruder N; Department of Anesthesia and Critical Care, Hôpital de la Timone, Aix-Marseille Université, 264 rue St-Pierre, 13005, Marseille, France. Nicolas.BRUDER@ap-hm.fr.
Higashida R; Department of Neuro Interventional Radiology, University of California San Francisco Medical Center, San Francisco, USA.
Santin-Janin H; Biometry, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Dubois C; Biometry, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Aldrich EF; Department of Neurosurgery, University of Maryland, Baltimore, USA.
Marr A; Global Clinical Development, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Roux S; Global Clinical Development, Idorsia Pharmaceuticals Ltd, Allschwil, Switzerland.
Mayer SA; Neurocritical Care and Emergency Neurology Services, Westchester Medical Center Health Network, Valhalla, USA.

BMC Neurol ; 22(1): 492, 2022 Dec 20.

Article em En | MEDLINE | ID: mdl-36539711

Assuntos

Isquemia Encefálica; Deterioração Clínica; Hemorragia Subaracnóidea; Vasoespasmo Intracraniano; Humanos; Hemorragia Subaracnóidea/complicações; Hemorragia Subaracnóidea/tratamento farmacológico; Estudos Prospectivos; Qualidade de Vida; Vasoespasmo Intracraniano/etiologia; Isquemia Encefálica/tratamento farmacológico; Isquemia Encefálica/etiologia; Isquemia Encefálica/prevenção & controle; Infarto Cerebral/etiologia

Palavras-chave

Aneurysm; Cerebral vasospasm; Clazosentan; Delayed cerebral ischemia; Subarachnoid hemorrhage

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Hemorragia Subaracnóidea / Isquemia Encefálica / Vasoespasmo Intracraniano / Deterioração Clínica Tipo de estudo: Clinical_trials / Etiology_studies / Observational_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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