(Thiolan-2-yl)diphenylmethanol Benzyl Ether-Catalyzed Asymmetric Cyclopropanation of Chalcones.
J Org Chem
; 88(1): 559-572, 2023 01 06.
Article
em En
| MEDLINE
| ID: mdl-36541794
ABSTRACT
We devised a new method for asymmetric cyclopropanation by employing (S)-(thiolan-2-yl)diphenylmethanol benzyl ether as an organocatalyst. Under optimal conditions, an in situ generated sulfur ylide reacts with (E)-chalcones via a Johnson-Corey-Chaykovsky reaction to afford a variety of cyclopropanes in excellent yields and stereoselectivities. This strategy employs low-environmental-risk reaction conditions and reusable catalysts. Hence, it is a green and efficient method for constructing cyclopropane scaffolds.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Chalconas
/
Éter
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article