A review of polydactyly and its inheritance: Connecting the dots.
Medicine (Baltimore)
; 101(50): e32060, 2022 Dec 16.
Article
em En
| MEDLINE
| ID: mdl-36550802
ABSTRACT
OBJECTIVE:
This study collects what is known about the inheritance underpinnings of syndromic and non-syndromic polydactylies and highlights dactyly presentations with unknown genetic roots. This review summarizes the current information and genetics-enhanced understanding of polydactyly.BACKGROUND:
There is a frequency of 0.37 to 1.2 per 1000 live births for polydactyly, which is also known as hyperdactyly. It is characterized by the presence of extra fingers. Polydactyly is caused by a failure in limb development, specifically the patterning of the developing limb bud. The phenotypic and genetic variability of polydactyly makes its etiology difficult to understand. Pre-axial polydactyly, central polydactyly (axial), and postaxial polydactyly are all examples of non-syndromic polydactyly (ulnar). An autosomal dominant disorder with varying penetrance that is mostly passed down via limb development patterning abnormalities.METHOD:
A comprehensive search of MEDLINE/PubMed and other databases was followed by an evaluation of the relevant papers, with a particular focus on those published between 2000 and 2022.RESULTS:
Of 747 published article related to Polydactyly from MEDLINE/PubMed search, 43 were from the last 10 years and were the focus of this review.CONCLUSION:
Polydactyly is one of the most frequent congenital hand malformations. PAP is more common than PPD, whereas central polydactyly is very uncommon.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polidactilia
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article