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Vaccine-Related Autoimmune Hepatitis: Emerging Association with SARS-CoV-2 Vaccination or Coincidence?
Trontzas, Ioannis P; Kyriakoulis, Konstantinos G; Vathiotis, Ioannis A; Syrigos, Alexandros; Kounadis, Georgios; Siasiakou, Sofia; Poulakou, Garyphalia.
Afiliação
  • Trontzas IP; 3rd Department of Internal Medicine, 'SOTIRIA' General Hospital of Chest Diseases, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Kyriakoulis KG; Department of Pathology, Yale University School of Medicine, New Haven, CT 06519, USA.
  • Vathiotis IA; 3rd Department of Internal Medicine, 'SOTIRIA' General Hospital of Chest Diseases, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Syrigos A; 3rd Department of Internal Medicine, 'SOTIRIA' General Hospital of Chest Diseases, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Kounadis G; 3rd Department of Internal Medicine, 'SOTIRIA' General Hospital of Chest Diseases, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Siasiakou S; 3rd Department of Internal Medicine, 'SOTIRIA' General Hospital of Chest Diseases, National and Kapodistrian University of Athens, 11527 Athens, Greece.
  • Poulakou G; 3rd Department of Internal Medicine, 'SOTIRIA' General Hospital of Chest Diseases, National and Kapodistrian University of Athens, 11527 Athens, Greece.
Vaccines (Basel) ; 10(12)2022 Dec 04.
Article em En | MEDLINE | ID: mdl-36560483
BACKGROUND: There is an increasing number of liver injury cases resembling autoimmune hepatitis (AIH) following SARS-CoV-2 vaccination; however, an association has not yet been established. METHODS/MATERIALS: A literature review was performed to identify articles regarding the association of AIH with vaccination, emphasizing on SARS-CoV-2 vaccines, and the proposed mechanisms. We then performed a literature search for AIH-like cases following SARS-CoV-2 vaccination, and we evaluated the included cases for AIH diagnosis using simplified diagnostic criteria (SDC), and for vaccination causality using the Naranjo score for adverse drug reactions. RESULTS: We identified 51 AIH-like cases following SARS-CoV-2 vaccination. Forty cases (80%) were characterized as "probable", "at least probable", or "definite" for AIH diagnosis according to SDC. Forty cases (78.4%) were characterized as "probable", four (7.8%) as "possible", and three (5.8%) as "definite" for vaccine-related AIH according to the Naranjo score. CONCLUSION: SARS-CoV-2 vaccine-related AIH carries several phenotypes and, although most cases resolve, immunosuppressive therapy seems to be necessary. Early diagnosis is mandatory and should be considered in any patient with acute or chronic hepatitis after SARS-CoV-2 vaccination, especially in those with pre-existing liver disease.
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Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Tipo de estudo: Prognostic_studies / Risk_factors_studies / Screening_studies Idioma: En Ano de publicação: 2022 Tipo de documento: Article