Nucleotide addition and cleavage by RNA polymerase II: Coordination of two catalytic reactions using a single active site.

Unarta, Ilona Christy; Goonetilleke, Eshani C; Wang, Dong; Huang, Xuhui

Unarta, Ilona Christy; Goonetilleke, Eshani C; Wang, Dong; Huang, Xuhui.

Afiliação

Unarta IC; Department of Chemistry, Theoretical Chemistry Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Goonetilleke EC; Department of Chemistry, Theoretical Chemistry Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA.
Wang D; Skaggs School of Pharmacy and Pharmaceutical Sciences, University of California, San Diego, La Jolla, California, USA; Department of Cellular and Molecular Medicine, School of Medicine, University of California, San Diego, La Jolla, California, USA; Department of Chemistry and Biochemistry, Universi
Huang X; Department of Chemistry, Theoretical Chemistry Institute, University of Wisconsin-Madison, Madison, Wisconsin, USA. Electronic address: xhuang@chem.wisc.edu.

J Biol Chem ; 299(2): 102844, 2023 02.

Article em En | MEDLINE | ID: mdl-36581202

Assuntos

Nucleotídeos; RNA Polimerase II; Catálise; Domínio Catalítico; Nucleotídeos/química; RNA; RNA Polimerase II/metabolismo; Magnésio/química

Palavras-chave

DNA transcription; RNA polymerase II; nucleotide addition; nucleotide cleavage; two-metal-ion mechanism

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Polimerase II / Nucleotídeos Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: RNA Polimerase II / Nucleotídeos Idioma: En Ano de publicação: 2023 Tipo de documento: Article