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Intravascularly infused extracellular matrix as a biomaterial for targeting and treating inflamed tissues.
Spang, Martin T; Middleton, Ryan; Diaz, Miranda; Hunter, Jervaughn; Mesfin, Joshua; Banka, Alison; Sullivan, Holly; Wang, Raymond; Lazerson, Tori S; Bhatia, Saumya; Corbitt, James; D'Elia, Gavin; Sandoval-Gomez, Gerardo; Kandell, Rebecca; Vratsanos, Maria A; Gnanasekaran, Karthikeyan; Kato, Takayuki; Igata, Sachiyo; Luo, Colin; Osborn, Kent G; Gianneschi, Nathan C; Eniola-Adefeso, Omolola; Cabrales, Pedro; Kwon, Ester J; Contijoch, Francisco; Reeves, Ryan R; DeMaria, Anthony N; Christman, Karen L.
Afiliação
  • Spang MT; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Middleton R; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Diaz M; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Hunter J; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Mesfin J; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Banka A; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Sullivan H; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Wang R; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Lazerson TS; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Bhatia S; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Corbitt J; Department of Chemical Engineering, University of Michigan, Ann Arbor, MI, USA.
  • D'Elia G; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Sandoval-Gomez G; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Kandell R; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Vratsanos MA; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Gnanasekaran K; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Kato T; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Igata S; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Luo C; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Osborn KG; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Gianneschi NC; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Eniola-Adefeso O; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Cabrales P; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Kwon EJ; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • Contijoch F; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Reeves RR; Shu Chien-Gene Lay Department of Bioengineering, University of California San Diego, La Jolla, CA, USA.
  • DeMaria AN; Sanford Consortium for Regenerative Medicine, La Jolla, CA, USA.
  • Christman KL; Department of Materials Science and Engineering, Northwestern University, Evanston, IL, USA.
Nat Biomed Eng ; 7(2): 94-109, 2023 02.
Article em En | MEDLINE | ID: mdl-36581694
ABSTRACT
Decellularized extracellular matrix in the form of patches and locally injected hydrogels has long been used as therapies in animal models of disease. Here we report the safety and feasibility of an intravascularly infused extracellular matrix as a biomaterial for the repair of tissue in animal models of acute myocardial infarction, traumatic brain injury and pulmonary arterial hypertension. The biomaterial consists of decellularized, enzymatically digested and fractionated ventricular myocardium, localizes to injured tissues by binding to leaky microvasculature, and is largely degraded in about 3 d. In rats and pigs with induced acute myocardial infarction followed by intracoronary infusion of the biomaterial, we observed substantially reduced left ventricular volumes and improved wall-motion scores, as well as differential expression of genes associated with tissue repair and inflammation. Delivering pro-healing extracellular matrix by intravascular infusion post injury may provide translational advantages for the healing of inflamed tissues 'from the inside out'.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Infarto do Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Materiais Biocompatíveis / Infarto do Miocárdio Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article