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CDT1, a licensing factor that limits rereplication.
Rona, Gergely; Pagano, Michele.
Afiliação
  • Rona G; Department of Biochemistry and Molecular Pharmacology, New York, NY 10016, USA; Laura and Isaac Perlmutter NYU Cancer Center, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University Grossman School of Medicine, New York, NY 10016, USA.
  • Pagano M; Department of Biochemistry and Molecular Pharmacology, New York, NY 10016, USA; Laura and Isaac Perlmutter NYU Cancer Center, New York, NY 10016, USA; Howard Hughes Medical Institute, New York University Grossman School of Medicine, New York, NY 10016, USA. Electronic address: michele.pagano@nyumc.org.
Mol Cell ; 83(1): 1-3, 2023 01 05.
Article em En | MEDLINE | ID: mdl-36608666
ABSTRACT
Cells must avoid licensing of neosynthesized DNA to prevent rereplication. In this issue of Molecular Cell, Ratnayeke et al. (2022)1 reveal how the licensing factor CDT1, prior to its degradation, inhibits DNA elongation by suppressing CMG helicase progression at replication forks.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Replicação do DNA Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteínas de Ciclo Celular / Replicação do DNA Idioma: En Ano de publicação: 2023 Tipo de documento: Article