Therapeutic reduction of GGGGCC repeat RNA levels by hnRNPA3 suppresses neurodegeneration in Drosophila models of C9orf72-linked ALS/FTD.

Taminato, Tomoya; Takeuchi, Toshihide; Ueyama, Morio; Mori, Kohji; Ikeda, Manabu; Mochizuki, Hideki; Nagai, Yoshitaka

Taminato, Tomoya; Takeuchi, Toshihide; Ueyama, Morio; Mori, Kohji; Ikeda, Manabu; Mochizuki, Hideki; Nagai, Yoshitaka.

Afiliação

Taminato T; Department of Neurology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.
Takeuchi T; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Ueyama M; Department of Neurology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.
Mori K; Life Science Research Institute, Kindai University, Osaka 589-8511, Japan.
Ikeda M; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.
Mochizuki H; Department of Neurology, Kindai University Faculty of Medicine, Osaka 589-8511, Japan.
Nagai Y; Department of Neurotherapeutics, Osaka University Graduate School of Medicine, Osaka 565-0871, Japan.

Hum Mol Genet ; 32(10): 1673-1682, 2023 05 05.

Article em En | MEDLINE | ID: mdl-36611007

Assuntos

Esclerose Lateral Amiotrófica; Demência Frontotemporal; Doença de Pick; Animais; Humanos; Demência Frontotemporal/patologia; Esclerose Lateral Amiotrófica/metabolismo; RNA/genética; RNA/metabolismo; Proteína C9orf72/genética; Drosophila/genética; Drosophila/metabolismo; Doença de Pick/genética; Proteínas/genética; Dipeptídeos/genética; Expansão das Repetições de DNA/genética

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Pick / Demência Frontotemporal / Esclerose Lateral Amiotrófica Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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