Cannabis Bioactive Compound-Based Formulations: New Perspectives for the Management of Orofacial Pain.
Molecules
; 28(1)2022 Dec 23.
Article
em En
| MEDLINE
| ID: mdl-36615298
ABSTRACT
The management of orofacial pain to alleviate the quality of life of affected patients is becoming increasingly challenging for scientific research and healthcare professionals. From this perspective, in addition to conventional therapies, new alternatives are being sought, increasingly looking at the use of both natural and synthetic products. Cannabis sativa L. represents an interesting source of bioactive compounds, including non-psychoactive cannabinoids, flavonoids, and terpenes, many of which are effective in improving pain intensity. Here, we aim to analyze the possible mechanisms of action of the bioactive natural and synthetic hemp-derived compounds responsible for the modulatory effects on pain-related pathways. The ability of these compounds to act on multiple mechanisms through a synergistic effect, reducing both the release of inflammatory mediators and regulating the response of the endocannabinoid system, makes them interesting agents for alternative formulations to be used in orofacial pain.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Canabinoides
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Cannabis
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Alucinógenos
Limite:
Humans
Idioma:
En
Ano de publicação:
2022
Tipo de documento:
Article