Allosteric Modulators of Dopamine D<sub>2</sub> Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis.

Kaczor, Agnieszka A; Wróbel, Tomasz M; Bartuzi, Damian

Allosteric Modulators of Dopamine D₂ Receptors for Fine-Tuning of Dopaminergic Neurotransmission in CNS Diseases: Overview, Pharmacology, Structural Aspects and Synthesis.

Kaczor, Agnieszka A; Wróbel, Tomasz M; Bartuzi, Damian.

Afiliação

Kaczor AA; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093 Lublin, Poland.
Wróbel TM; School of Pharmacy, University of Eastern Finland, Yliopistonranta 1, P.O. Box 1627, FI-70211 Kuopio, Finland.
Bartuzi D; Department of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, 4A Chodzki St., PL-20093 Lublin, Poland.

Molecules ; 28(1)2022 Dec 25.

Article em En | MEDLINE | ID: mdl-36615372

Assuntos

Doenças do Sistema Nervoso Central; Dopamina; Humanos; Regulação Alostérica; Sítio Alostérico; Doenças do Sistema Nervoso Central/tratamento farmacológico; Dopamina/metabolismo; Ligantes; Receptores Dopaminérgicos; Transmissão Sináptica

Palavras-chave

G protein-couple receptors; allosteric modulation; dopamine D2 receptor; drug synthesis; molecular modeling

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Dopamina / Doenças do Sistema Nervoso Central Limite: Humans Idioma: En Ano de publicação: 2022 Tipo de documento: Article

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