A Rough Colony Morphology of Mycobacterium abscessus Is Associated With Cavitary Pulmonary Disease and Poor Clinical Outcome.
J Infect Dis
; 227(6): 820-827, 2023 03 28.
Article
em En
| MEDLINE
| ID: mdl-36637124
ABSTRACT
BACKGROUND:
The Mycobacterium abscessus complex (MABC) is a difficult to treat mycobacterium with two distinct morphologies smooth and rough. As the clinical implications are unclear, we explored the morphology of MABC in relation to disease and outcome.METHODS:
We performed a retrospective multicenter cohort study including patients with confirmed MABC in Sweden, 2009-2020, with treatment outcome as the primary outcome. MABC colony morphology was determined by light microscopy on Middlebrook 7H10 agar plates.RESULTS:
Of the 71 MABC isolates, a defined morphology could be determined for 63 isolates, of which 40 were smooth (56%) and 23 were rough (32%). Immunosuppression, pulmonary disease, and cavitary lesion on chest radiographs were significantly associated with a rough isolate morphology. Participants with smooth isolates had more favorable treatment outcomes (12/14, 86%) compared to those with rough isolates (3/10, 30%). In an age-adjusted logistic regression, rough morphology of MABC was associated to lower odds of clinical cure compared to smooth morphology (adjusted odds ratio, 0.12; P = .049).CONCLUSIONS:
Study participants with rough MABC colony morphology of isolates had a worse clinical outcome compared to those with smooth isolates. The biological mechanisms should be further characterized and colony morphology of MABC taken into account during clinical management.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Mycobacterium abscessus
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Pneumopatias
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Infecções por Mycobacterium não Tuberculosas
Tipo de estudo:
Clinical_trials
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Etiology_studies
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Incidence_studies
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Observational_studies
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Risk_factors_studies
Limite:
Humans
País como assunto:
Europa
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article