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Sustained Diet-Induced Remission in Pediatric Crohn's Disease Is Associated With Kynurenine and Serotonin Pathways.
Ghiboub, Mohammed; Boneh, Rotem Sigall; Sovran, Bruno; Wine, Eytan; Lefèvre, Antoine; Emond, Patrick; Verburgt, Charlotte M; Benninga, Marc A; de Jonge, Wouter J; Van Limbergen, Johan E.
Afiliação
  • Ghiboub M; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
  • Boneh RS; Department of Pediatric Gastroenterology and Nutrition, Emma Children's Hospital, Amsterdam University Medical Centers, Amsterdam, Netherlands.
  • Sovran B; Division of Pediatric Gastroenterology, Wolfson Medical Centre, Holon, Sackler Faculty of Medicine, Tel Aviv University, Tel Aviv, Israel.
  • Wine E; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
  • Lefèvre A; Department of Pediatric Surgery, Amsterdam Reproduction and Development Research Institute, Emma Children's Hospital, Amsterdam UMC, University of Amsterdam and Vrije Universiteit Amsterdam, Amsterdam, the Netherlands.
  • Emond P; Division of Pediatric Gastroenterology, Department of Pediatrics, University of Alberta, Edmonton, AB, Canada.
  • Verburgt CM; UMR 1253, iBrain, INSERM, University of Tours, Tours, France.
  • Benninga MA; UMR 1253, iBrain, INSERM, University of Tours, Tours, France.
  • de Jonge WJ; Laboratoire de Médecine Nucléaire In Vitro, Centre Hospitalier Régionale Universitaire de Tours, Tours, France.
  • Van Limbergen JE; Tytgat Institute for Liver and Intestinal Research, Amsterdam Gastroenterology Endocrinology Metabolism, Academic Medical Center, University of Amsterdam, Amsterdam, Netherlands.
Inflamm Bowel Dis ; 29(5): 684-694, 2023 05 02.
Article em En | MEDLINE | ID: mdl-36637175
We show that fecal tryptophan metabolites are associated with remission following dietary therapy in a prospective clinical trial of pediatric Crohn's disease patients. Our study shows that reduction in some kynurenine pathway metabolites and the increase in serotonin pathway compounds are associated with diet-induced and sustained remission. These compounds may play a role in mediating the mechanism of action of dietary therapy.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Crohn / Melatonina Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doença de Crohn / Melatonina Tipo de estudo: Clinical_trials / Observational_studies / Risk_factors_studies Limite: Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article