Definitive treatment and risk of death among men diagnosed with metastatic prostate cancer at the Veterans Health Administration.
Ann Epidemiol
; 79: 24-31, 2023 03.
Article
em En
| MEDLINE
| ID: mdl-36640917
ABSTRACT
PURPOSE:
To assess the potential survival benefit associated with receipt of definitive treatment (radical prostatectomy or radiation), compared to non-definitive treatment (hormonal therapy or chemotherapy) among men with metastatic prostate cancer.METHODS:
A cohort of men diagnosed with metastatic (T4/M1/N1 or T4/M1) prostate cancer from 1999 to 2013 in the Veterans Health Administration were identified and followed to December 28, 2014. All-cause and prostate cancer-specific mortality were evaluated at 10 years for the T4/M1/N1 cohort and 8 years for the T4/M1/ cohort. The association of definitive treatment (radical prostatectomy or radiation), compared to non-definitive (hormonal therapy or chemotherapy) with both all-cause and prostate cancer-specific mortality was assessed using inverse probability of treatment weighted (IPTW) multivariable survival analyses.RESULTS:
The cohort included 2919 with T4/M1/N1 disease and 1479 men with T4/M1 disease. Receipt of definitive treatment was associated with a reduced risk of 10-year all-cause (Hazard Ratio (HR) 0.61; 95% Confidence Interval (CI) 0.57-0.65) and prostate cancer-specific mortality (HR 0.50; 95% CI 0.46-0.55) among men diagnosed with T4/M1/N1 met-astatic disease. Definitive treatment was similarly associated with a reduced risk of all-cause (HR 0.84; 95% CI 0.77-0.91) and prostate cancer-specific (HR 0.81; 95% CI 0.73-0.90) mortality among men diagnosed with T4/M1 only metastatic disease.CONCLUSIONS:
Definitive treatment may improve survival in men diagnosed with metastatic prostate cancer.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias da Próstata
/
Saúde dos Veteranos
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
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Risk_factors_studies
Limite:
Humans
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Male
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article