A curcumin analogue GO-Y030 depletes cancer stem cells by inhibiting the interaction between the HSP70/HSP40 complex and its substrates.

Suzuki, Maya; Yamamoto, Yohei; Nishijima-Matsunobu, Aki; Kawasaki, Yohei; Shibata, Hiroyuki; Omori, Yasufumi

Suzuki, Maya; Yamamoto, Yohei; Nishijima-Matsunobu, Aki; Kawasaki, Yohei; Shibata, Hiroyuki; Omori, Yasufumi.

Afiliação

Suzuki M; Department of Molecular and Tumour Pathology, Akita University Graduate School of Medicine, Japan.
Yamamoto Y; Department of Molecular and Tumour Pathology, Akita University Graduate School of Medicine, Japan.
Nishijima-Matsunobu A; Department of Molecular and Tumour Pathology, Akita University Graduate School of Medicine, Japan.
Kawasaki Y; Department of Otorhinolaryngology and Head-and-Neck Surgery, Akita University Graduate School of Medicine, Japan.
Shibata H; Department of Clinical Oncology, Akita University Graduate School of Medicine, Japan.
Omori Y; Department of Molecular and Tumour Pathology, Akita University Graduate School of Medicine, Japan.

FEBS Open Bio ; 13(3): 434-446, 2023 03.

Article em En | MEDLINE | ID: mdl-36648092

Assuntos

Curcumina; Humanos; Curcumina/farmacologia; Proteínas de Choque Térmico HSP40/metabolismo; Linhagem Celular Tumoral; Recidiva Local de Neoplasia; Proteínas de Choque Térmico HSP70/metabolismo; Células-Tronco Neoplásicas/metabolismo

Palavras-chave

HSP70 inhibitors; cancer stem cells; curcumin analogue; heat shock proteins; protein refolding; stress response

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Curcumina Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Curcumina Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article