Applications of microphysiological systems to disease models in the biopharmaceutical industry: Opportunities and challenges.

Irrechukwu, Onyi; Yeager, Ronnie; David, Rhiannon; Ekert, Jason; Saravanakumar, Anitha; Choi, Colin K

Irrechukwu, Onyi; Yeager, Ronnie; David, Rhiannon; Ekert, Jason; Saravanakumar, Anitha; Choi, Colin K.

Afiliação

Irrechukwu O; Preclinical Sciences and Translational Safety, Janssen Research and Development, LLC, Spring House, PA, USA.
Yeager R; Preclinical Safety, AbbVie, North Chicago, IL, USA.
David R; Safety Innovation, Clinical Pharmacology & Safety Sciences, R&D, AstraZeneca, Cambridge, UK.
Ekert J; US Discovery, Early Solutions, UCB, Cambridge, MA, USA.
Saravanakumar A; Drug Metabolism and Pharmacokinetics, Takeda Pharmaceutical Company Ltd., Cambridge, MA, USA.
Choi CK; Preclinical Safety, Biogen, Cambridge, MA, USA.

ALTEX ; 40(3): 485-518, 2023.

Article em En | MEDLINE | ID: mdl-36648096

Assuntos

Produtos Biológicos; COVID-19; Animais; Humanos; Sistemas Microfisiológicos; Qualidade de Vida; Fígado; Dispositivos Lab-On-A-Chip

Palavras-chave

animal model alternatives; drug development; drug discovery; in vitro models; organ-on-a-chip complex

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Produtos Biológicos / COVID-19 Tipo de estudo: Guideline Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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