Gene therapy for chronic pain: emerging opportunities in target-rich peripheral nociceptors.
Nat Rev Neurosci
; 24(4): 252-265, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36658346
ABSTRACT
With sweeping advances in precision delivery systems and manipulation of the genomes and transcriptomes of various cell types, medical biotechnology offers unprecedented selectivity for and control of a wide variety of biological processes, forging new opportunities for therapeutic interventions. This perspective summarizes state-of-the-art gene therapies enabled by recent innovations, with an emphasis on the expanding universe of molecular targets that govern the activity and function of primary sensory neurons and which might be exploited to effectively treat chronic pain.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Nociceptores
/
Dor Crônica
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article