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Influence of the endothelium on the amplification by serotonin of vasoconstrictor responses to noradrenaline and sympathetic nerve stimulation in rabbit isolated ear artery.
Meehan, A G; Story, D F; Medgett, I C.
Afiliação
  • Meehan AG; Department of Pharmacology, University of Melbourne, Victoria, Australia.
Eur J Pharmacol ; 141(3): 339-46, 1987 Sep 23.
Article em En | MEDLINE | ID: mdl-3666031
The influence of the vascular endothelium on the amplifying effect of serotonin on steady-state responses to noradrenaline (NA) and sympathetic nerve stimulation (SNS) has been studied in the rabbit isolated ear artery. Removal of the endothelium abolished the dilator effect of acetylcholine (ACh, 1 microM) obtained in the presence of NA (0.3 microM). Responses to NA were increased after endothelium removal; however, responses to SNS were unaffected. Serotonin in a concentration which did not itself produce vasoconstriction (100 nM) increased responses of endothelium-intact preparations to NA and SNS and of endothelium-denuded preparations to SNS but had no effect on NA responses of endothelium-denuded preparations. If neuronal uptake was inhibited with cocaine (1 microM), serotonin markedly amplified responses to NA and SNS in both endothelium-intact and endothelium-denuded preparations. These results suggest that the endothelium influences the amplifying effect of serotonin on responses of rabbit ear artery to NA but not to SNS. Inhibition of removal of serotonin and NA by neuronal uptake may extend the facilitatory interaction between NA and serotonin to smooth muscle cells which are not subject to the inhibitory influence of an endothelium derived relaxing factor.
Assuntos
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Base de dados: MEDLINE Assunto principal: Sistema Nervoso Simpático / Vasoconstrição / Endotélio Vascular / Serotonina / Norepinefrina Limite: Animals Idioma: En Ano de publicação: 1987 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Sistema Nervoso Simpático / Vasoconstrição / Endotélio Vascular / Serotonina / Norepinefrina Limite: Animals Idioma: En Ano de publicação: 1987 Tipo de documento: Article