Catecholamine content and adenylate cyclase activity in corpora lutea of different ages of the PMSG-treated immature rat.
Mol Cell Endocrinol
; 53(3): 155-60, 1987 Oct.
Article
em En
| MEDLINE
| ID: mdl-3666296
ABSTRACT
The catecholamine content and adenylate cyclase response were studied in a well-characterized corpus luteum model, where ovulation was induced by treatment of prepubertal Sprague-Dawley rats with pregnant mare's serum gonadotropin. The luteal content of noradrenaline, determined with HPLC, was constant during the first 7 days of pseudopregnancy, followed by a 3-fold increase in older corpora lutea. No detectable amounts of dopamine were found, while trace amounts of adrenaline were found in a few cases. The increase in noradrenaline content was not associated with a changed sensitivity of luteal adenylate cyclase to catecholamines. The response to adrenaline was maximal in 3-day-old corpora lutea, whereafter a decrease was seen. The significance of the increased endogenous levels of noradrenaline at the end of pseudopregnancy is at present unknown. However, the fact that the increase in noradrenaline occurs a few days before spontaneous luteolysis is of special interest, since it has been suggested that an adrenergic innervation is a prerequisite for the antigonadotropic effect of prostaglandin F2 alpha in the human corpus luteum.
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Base de dados:
MEDLINE
Assunto principal:
Catecolaminas
/
Adenilil Ciclases
/
Gonadotropinas Equinas
/
Corpo Lúteo
Limite:
Animals
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article