The ends in sight: Mre11-Rad50-Nbs1 complex structures come into focus.
Mol Cell
; 83(2): 160-162, 2023 Jan 19.
Article
em En
| MEDLINE
| ID: mdl-36669476
ABSTRACT
In this issue of Molecular Cell, Rotheneder et al.1 elucidate the eukaroytic Mre11-Rad50-Nbs1 (MRN) complex quaternary architecture, which together with cryo-EM structures of bacterial Mre11-Rad50-DNA complexes,2 resolves the basis for MRN assembly and its broad nuclease specificity regulating DNA double-strand break repair.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Proteínas de Ciclo Celular
/
Enzimas Reparadoras do DNA
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article