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Site-specific nanomodulator capable of modulation apoptosis for enhanced colorectal cancer chemo-photothermal therapy.
Wang, Shuqi; Zhou, Li; Tian, Hailong; Li, Bowen; Su, Miao; Li, Qiong; Nice, Edouard C; Huang, Canhua; Shao, Jichun; He, Tao.
Afiliação
  • Wang S; Institute for Cancer Medicine, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China.
  • Zhou L; Key Laboratory of Molecular Biology for Infectious Diseases (Ministry of Education), Institute for Viral Hepatitis, Department of Infectious Diseases, the Second Affiliated Hospital, Chongqing Medical University, Chongqing, 400016, China.
  • Tian H; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China, School of Basic Medical Sciences and Forensic Medicine, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, 610041, China.
  • Li B; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China, School of Basic Medical Sciences and Forensic Medicine, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, 610041, China.
  • Su M; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China, School of Basic Medical Sciences and Forensic Medicine, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, 610041, China.
  • Li Q; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China, School of Basic Medical Sciences and Forensic Medicine, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, 610041, China.
  • Nice EC; Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC, 3800, Australia.
  • Huang C; State Key Laboratory of Biotherapy and Cancer Center, West China Hospital, and West China, School of Basic Medical Sciences and Forensic Medicine, Collaborative Innovation Center for Biotherapy, Sichuan University, Chengdu, 610041, China.
  • Shao J; The Second Affiliated Hospital of Chengdu Medical College, China National Nuclear Corporation 416 Hospital, Chengdu, 610051, Sichuan, China. shaoji93@163.com.
  • He T; Institute for Cancer Medicine, School of Basic Medical Sciences, Southwest Medical University, Luzhou, 646000, Sichuan, China. hetao198@swmu.edu.cn.
J Nanobiotechnology ; 21(1): 24, 2023 Jan 20.
Article em En | MEDLINE | ID: mdl-36670444
BACKGROUND: Colorectal cancer (CRC) is a common malignancy with the second highest mortality and the third highest morbidity worldwide. However, the overall survival of patients is unsatisfactory, thus requiring more effective clinical strategies. Celastrol (CLT), a natural bioactive compound, has been reported to induce reactive oxygen species (ROS)-mediated apoptosis to exhibit significant antitumor effects against CRC. However, the poor water solubility, low targeting ability, and bioavailability of CLT have limited its application, and CLT-induced protective autophagy weakens its therapeutic efficiency. RESULTS: We designed a targeted chemo-phototherapy nanoplatform (HCR NPs) to improve the application of CLT. The codelivery of IR820 and CLT in HCR NPs solved the water-soluble problem of CLT and enhanced apoptosis via IR820-mediated hyperthermia. In addition, hydroxychloroquine (HCQ) conjugated to hyaluronic acid (HA) not only increased the active targeting of HCR NPs but also inhibited CLT-induced protective autophagy to exacerbate apoptosis, thus achieving an amplified antitumor effect. Importantly, the HCR NPs exhibited an excellent therapeutic effect on CRC both in vitro and in vivo. CONCLUSION: The HCR NPs presented in this study may not merely provide a new reference for the clinical application of CLT but also result in an attractive strategy for CRC treatment.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Nanopartículas / Hipertermia Induzida Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Nanopartículas / Hipertermia Induzida Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article