IRF8 Regulates Intrinsic Ferroptosis through Repressing p53 Expression to Maintain Tumor Cell Sensitivity to Cytotoxic T Lymphocytes.

Poschel, Dakota B; Kehinde-Ige, Mercy; Klement, John D; Yang, Dafeng; Merting, Alyssa D; Savage, Natasha M; Shi, Huidong; Liu, Kebin

Poschel, Dakota B; Kehinde-Ige, Mercy; Klement, John D; Yang, Dafeng; Merting, Alyssa D; Savage, Natasha M; Shi, Huidong; Liu, Kebin.

Afiliação

Poschel DB; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Kehinde-Ige M; Georgia Cancer Center, Augusta, GA 30912, USA.
Klement JD; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.
Yang D; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Merting AD; Georgia Cancer Center, Augusta, GA 30912, USA.
Savage NM; Department of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta, GA 30912, USA.
Shi H; Georgia Cancer Center, Augusta, GA 30912, USA.
Liu K; Charlie Norwood VA Medical Center, Augusta, GA 30904, USA.

Cells ; 12(2)2023 01 13.

Article em En | MEDLINE | ID: mdl-36672246

Assuntos

Ferroptose; Neoplasias; Animais; Humanos; Camundongos; Ferroptose/genética; Fatores Reguladores de Interferon/metabolismo; Linfócitos T Citotóxicos/metabolismo; Proteína Supressora de Tumor p53/genética

Palavras-chave

IRF8; cancer immunotherapy; ferroptosis; lipid nanoparticle gene therapy; p53; tumor cell death

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Ferroptose / Neoplasias Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

Imprimir

XML

PubMed Links

Buscar no Google