Isosarcophytoxide Derivatives with a 2,5-Dihydrofuran Moiety from the Soft Coral Sarcophyton cinereum.
Molecules
; 28(2)2023 Jan 08.
Article
em En
| MEDLINE
| ID: mdl-36677699
ABSTRACT
The present chemical investigation on the organic extract of the soft coral Sarcophyton cinereum has contributed to the isolation of four new cembranoids 16ß- and 16α-hydroperoxyisosarcophytoxides (1 and 2), 16ß- and 16α-methoxyisosarcophytoxides (3 and 4), and a known cembranoid, lobocrasol (5). The structures of all isolates were elucidated by detailed spectroscopic analysis. Their structures were characterized by a 2,5-dihydrofuran moiety, of which the relative configuration was determined by DU8-based calculation for long-range coupling constants (4JH,H). The cytotoxicity and immunosuppressive activities of all isolates were evaluated in this study.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Antozoários
/
Diterpenos
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article